The flagship triple combination. Targets mitochondrial biology across structural support, signalling input, and coenzyme availability. Research use only.
The flagship triple combination of modern mitochondrial research. SS-31, MOTS-c, and NAD+ each act on a different layer of cellular energy biology — structure, signalling, and coenzyme availability — making this three-compound preparation one of the most ambitious research blends in the longevity category.
The three compounds operate at distinct but interconnected points in mitochondrial biology. SS-31 supports the membrane environment in which oxidative phosphorylation occurs. MOTS-c provides upstream signalling input affecting energy substrate use. NAD+ serves as the required coenzyme for the redox reactions driving ATP synthesis and downstream sirtuin signalling. The composition is designed for research into integrated approaches to mitochondrial function across structural, signalling, and substrate-level inputs simultaneously.
SS-31 has progressed through clinical trials in specific therapeutic contexts. NAD+ and its precursors (NMN, NR) have been the subject of a growing body of human studies. MOTS-c remains earlier in its research trajectory. The three-compound combination itself hasn't been subject to large-scale clinical investigation
Published studies on the individual compounds have explored:
Mitochondrial efficiency: Improved ATP output and reduced oxidative stress markers across cell and animal models.
Metabolic regulation: Improvements in glucose handling, insulin sensitivity, and lipid metabolism, primarily in animal models.
Skeletal muscle function: Enhanced exercise capacity and mitochondrial biogenesis in animal models, with relevance to "exercise mimetic" research.
Cardiac research: SS-31 has been studied in heart failure and ischemic injury models.
Ageing-related research: All three compounds have been examined for effects on age-associated decline, with NAD+ research particularly active in this space.
Combined-administration data is limited.
This landmark preclinical study demonstrated that restoring NAD+ levels can completely reverse age-related mitochondrial dysfunction, effectively turning back the biological clock in mammalian tissues.
This study specifically analysed whether treating mice at advanced ages with SS-31 could reverse established markers of physical decline.
As Seen In The Press
Peptides can affect the way the body functions at a cellular level.
Pre-filled Cartridges
Engineered for absolute accuracy and ease. Our pre-blended pens make precise dosing completely seamless in just three quick steps.
Step 1 - Remove the Pre-mixed pen from the box
Step 2 - Secure the needle tip
Step 3 - Twist to set the required dose
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