The molecule at the centre of longevity science. A foundational coenzyme for redox biology and a required substrate for sirtuins, PARPs, and CD38. Research use only.
The molecule at the centre of modern longevity science. NAD+ is a coenzyme present in every living cell, and the foundation of an entire research field — sirtuin biology, mitochondrial function, DNA repair, and ageing-related decline all converge on it. Few molecules have generated as much research excitement in the past two decades.
NAD+ plays two distinct biological roles. First, it's a redox coenzyme — accepting and donating electrons in glycolysis, the TCA cycle, and oxidative phosphorylation. Second, it's a required substrate for NAD+-consuming enzymes: sirtuins (regulating gene expression, mitochondrial biogenesis, and stress response), PARPs (mediating DNA repair), and CD38 (calcium signalling and immune function). The balance between these roles — and how it shifts with age — is one of the hottest topics in current ageing research.
NAD+ and its precursors are among the most actively researched compounds in modern longevity science, with a growing body of human trial data — primarily for NMN and NR rather than NAD+ itself. NAD+ administration in research contexts is studied in a range of formulations, with delivery and stability being practical considerations.
The NAD+ literature is one of the largest in current ageing and metabolic biology:
Ageing research: Documented age-related NAD+ decline across multiple tissues and species.
Sirtuin biology: Extensive investigation of NAD+-dependent sirtuin activity in metabolic regulation, DNA repair, and stress response.
Mitochondrial function: Studies on NAD+ availability and mitochondrial biogenesis.
NAD+ precursors: Parallel research on NMN and NR as repletion strategies, with multiple completed human trials.
Metabolic disease: Investigation in obesity, type 2 diabetes, and metabolic syndrome models.
Neurodegeneration: Studies in Alzheimer's, Parkinson's, and other neurodegenerative models.
This landmark preclinical study demonstrated that restoring NAD+ levels can completely reverse age-related mitochondrial dysfunction, effectively turning back the biological clock in mammalian tissues.
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Peptides can affect the way the body functions at a cellular level.
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