A legend of dermatological research. A copper-binding tripeptide with four decades of research literature in collagen synthesis and tissue remodelling. Research use only.
A legend of dermatological research — GHK-Cu has been studied continuously for more than four decades, making it one of the most thoroughly investigated peptides in the entire tissue repair category. This naturally occurring copper-binding tripeptide has driven research in collagen synthesis, gene expression, wound healing, and skin biology that few peptides can match for sheer depth of literature.
GHK-Cu is a tripeptide (glycyl-L-histidyl-L-lysine) complexed with a copper(II) ion. It functions both as a copper carrier and as a signalling molecule with remarkable breadth. Research documents effects on collagen and elastin synthesis, modulation of matrix metalloproteinases, antioxidant activity via copper-dependent enzyme systems (including superoxide dismutase), and influence on gene expression patterns linked to tissue remodelling and ageing. Gene-expression studies have reported GHK-Cu modulating the activity of an extraordinary number of genes related to regeneration and ageing.
GHK-Cu has a substantial published literature in dermatology and cosmetic science, and is widely used in topical research formulations. Its use in injectable or systemic research is more recent and less thoroughly characterised.
Dermal research: Effects on collagen synthesis, skin barrier function, wound healing, and dermal ageing markers.
Hair follicle research: Studies on follicle size, anagen-phase induction, and hair growth in animal and human models.
Tissue repair: Bone, cartilage, and stomach lining repair in animal models.
Antioxidant and anti-inflammatory activity: Reductions in oxidative stress markers across multiple tissue types.
Gene expression: Microarray studies showing modulation of regeneration- and ageing-related genes, with research extending into cancer-related gene expression signatures.
This clinical human trial evaluated GHK-Cu's ability to heal severe, chronic open wounds (diabetic ulcers) that traditionally resist conventional medical treatment.
As Seen In The Press
Peptides can affect the way the body functions at a cellular level.
Pre-filled Cartridges
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