5-Amino-1MQ – 100mg

A small-molecule research compound making serious noise in fat metabolism and adipose tissue science. By blocking the NNMT enzyme — a key regulator linked to obesity and ageing — 5-Amino-1MQ has opened up an entirely new angle on metabolic research.

5-Amino-1MQ inhibits nicotinamide N-methyltransferase (NNMT), an enzyme that plays a central role in adipose tissue biology, nicotinamide metabolism, and the cellular NAD+ pool. NNMT expression is elevated in obesity, which is why researchers are so interested in what happens when its activity is dialled down. Note that despite often being grouped with research peptides, 5-Amino-1MQ is actually a small-molecule quinolinium-based inhibitor — not a peptide.

5-Amino-1MQ is at an early stage — almost all the data is preclinical, with no large-scale human trials yet. It's primarily used as a research tool to probe NNMT biology in metabolic and ageing studies.

Adipose tissue and fat metabolism: Animal studies have reported reduced fat mass and increased energy expenditure after NNMT inhibition.
Insulin sensitivity: Improved glucose handling and insulin response in diet-induced obesity models.
Inflammation: Reductions in certain inflammatory markers.
Muscle and tissue research: Studies examining NNMT's role in skeletal muscle function and age-related tissue changes.
Dermal research: Investigation in skin barrier and fibroblast function.