Professional Title: “Tendon, Ligament, and Muscle Injury: Therapeutic Perspectives of Stable Gastric Pentadecapeptide BPC-157 in Complex Musculoskeletal and Junctional Recovery”
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Journal Context: MDPI Pharmaceuticals (Published February 2026) | Identifiers: DOI: 10.3390/ph19020309 / PMID: 41754849
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Principal Investigators: Seiwerth, S., Sikiric, P., et al. (Department of Pathology, School of Medicine, University of Zagreb)
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Methodology: A multi-model systematic tracking of injury recovery following direct exogenous administration of BPC-157 across systemic (intragastric, intraperitoneal, drinking water) and topical modalities in rat models with surgical quadriceps detachment and complex myotendinous lacerations.
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Key Findings: Unlike typical growth factors that often fail during isolated muscle tissue repair, BPC-157 combined beneficial repair effects across tendon, ligament, and muscle fibers simultaneously. Active cohorts showed accelerated callus mineralization and lamellar bone formation over fibrous scar tissue, demonstrating superior biomechanical recovery at the osteotendinous and myotendinous junctions without relying on complex structural scaffolds.