Tag: LL-37
Melanotan II Injection for Erectile Dysfunction Evaluation:
By linking the amino acid backbone into a ring structure via a lactam bridge, researchers drastically increased its structural rigidity. This compact, cyclical shape allows MT-2 to cross the Blood-Brain Barrier (BBB), triggering a non-selective activation profile across both peripheral skin receptors and central nervous system receptors.
Efficacy and Safety of Afamelanotide (Melanotan I) in Patients with Erythropoietic Protoporphyria
To prevent rapid enzymatic breakdown, molecular engineers substituted native Methionine with Norleucine (Nle) and replaced L-Phenylalanine with D-Phenylalanine.
Vasoactive Intestinal Peptide and Long-Lasting Pacing of Central Nervous System Circadian Activity
This neurological study tracks how VIP orchestrates the central biological clock, proving that it controls long-term electrical firing frequencies within the brain’s primary pacing architecture.
Reversal of Cognitive Defects and Synaptic Deficits with P21
This longitudinal evaluation tracked what happens when P21 is administered prior to the full accumulation of neurodegenerative plaques, assessing its ability to prevent cognitive and physical structural decay.
Peak Activation Velocities and TREK-1 Channel Inhibition with PE-22-28
This foundational mechanical study established the exact binding potency of PE-22-28, proving that it matches or outperforms standard antidepressants at a fraction of the molecular size.
Clinical Trial on Chronic Insomnia and Sleep Architecture
This double-blind human clinical trial evaluated the efficacy and safety of DSIP administration in patients suffering from severe chronic sleep disturbances.
Amelioration of Alzheimer’s-Type Pathological Impairments with Semax
This modern translational study evaluates Semax’s potential to counteract advanced neurodegenerative states, documenting its ability to clear toxic amyloid-beta accumulation and rescue cognitive performance.
Comparison of Selank Against Traditional Benzodiazepines
This human clinical study evaluated the therapeutic efficacy of Selank in patients diagnosed with Generalized Anxiety Disorder (GAD), comparing its performance head-to-head against the traditional benzodiazepine medication Phenazepam.
Trial Evaluating the Effects of ACE-031 on Muscle Mass Expansion
This randomised, double-blind human clinical trial evaluated the safety, tolerability, and muscle-building potency of a single dose of ACE-031 in healthy, postmenopausal women.
Geroprotective Efficacy of Thymalin Injections in Elderly Populations
This landmark, long-term human clinical trial evaluated the survival rates and immune parameters of advanced-age adults administered regular cycles of Thymalin over a multi-year monitoring period.