Tesamorelin has the strongest clinical evidence base of any GHRH analogue currently studied, with regulatory authorisation in a specific HIV-related indication and active ongoing research in hepatic and cognitive contexts.
Visceral adipose tissue: Clinical trials reported reductions in visceral fat in HIV-associated lipodystrophy cohorts — the indication for which it received regulatory approval.
GH and IGF-1 dynamics: Sustained IGF-1 elevation within physiological ranges.
Cognitive research: Studies examining cognitive performance in older adults and mild cognitive impairment cohorts.
NAFLD research: Investigation in non-alcoholic fatty liver disease with reported reductions in hepatic fat fraction.